Lower Blood Phe with NeoPhe.
Clinically proven combination of large neutral amino acids (LNAA) that block Phenylalanine at the gut level resulting in lower blood Phenylalanine.
- Data from pilot studies conducted in Ukraine, Russia and the US revealed a decrease in blood Phe concentration of 52%-55% form baseline. When NeoPhe was discontinued, blood Phe concentrations increased to pre-trial levels. 1
- Double blind studies performed in seven (7) different centers indicate that LNAA can compete with Phe on the transporter in the GI tract, resulting in a decrease in the blood phe-level in patients on NeoPhe, averaging 39% from baseline levels. 2
- Adults, teenagers and children 8 years or older
- BH4 non-responders
- High blood Phe levels despite strong diet compliance
- Non compliant, untreated or late-diagnosed PKU patients
- Monitor blood Phe levels for tolerance.
- NeoPhe tablets and powder can be used interchangeably.
- NeoPhe results in liberalization of the diet for most PKU patients.
- Decrease in consumption of low protein foods.
1) R. Matalon, K. Michals-Matalon, G. Bhatia, E. Grechanina, P. Novikov, D. J. McDonald, J. Grady, S.K. Tyring, F. Guttler, Large Neutral Amino Acids in the Treatment of Phenylketonuria (PKU), J Inherit Metab Dis. 2006 Dec;29(6):732-8.
2) R. Matalon, K. Michals-Matalon, G. Bhatia, A.B. Burlina, A.P. Burlina, C. Braga, L. Fiori, M. Giovannini, E. Grechanina, P. Novikov, J. Grady, S.K. Tyring, F.Guttler, Double blind placebo control trial of large neutral amino acids in treatment of PKU: Effect on blood phenylalanine. J Inherit Metab Dis. 2007, Feb 27.