Lower Blood Phe with NeoPhe.
Clinically proven combination of large neutral amino acids (LNAA) that block Phenylalanine at the gut level resulting in lower blood Phenylalanine.

Clinically Proven

  • Data from pilot studies conducted in Ukraine, Russia and the US revealed a decrease in blood Phe concentration of 52%-55% form baseline. When NeoPhe was discontinued, blood Phe concentrations increased to pre-trial levels. 1
  • Double blind studies performed in seven (7) different centers indicate that LNAA can compete with Phe on the transporter in the GI tract, resulting in a decrease in the blood phe-level in patients on NeoPhe, averaging 39% from baseline levels. 2


  • Adults, teenagers and children 8 years or older
  • BH4 non-responders
  • High blood Phe levels despite strong diet compliance
  • Non compliant, untreated or late-diagnosed PKU patients


  • Monitor blood Phe levels for tolerance.
  • NeoPhe tablets and powder can be used interchangeably.
  • NeoPhe results in liberalization of the diet for most PKU patients.
  • Decrease in consumption of low protein foods.

1) R. Matalon, K.  Michals-Matalon, G. Bhatia, E. Grechanina, P. Novikov, D. J. McDonald, J. Grady, S.K. Tyring, F. Guttler, Large Neutral Amino Acids in the Treatment of Phenylketonuria (PKU), J Inherit Metab Dis. 2006 Dec;29(6):732-8. 
 R. Matalon, K. Michals-Matalon, G. Bhatia, A.B. Burlina, A.P. Burlina, C. Braga, L. Fiori, M. Giovannini, E. Grechanina, P. Novikov, J. Grady, S.K. Tyring,  F.Guttler, Double blind placebo control trial of large neutral amino acids in treatment of PKU: Effect on blood phenylalanine. J Inherit Metab Dis. 2007, Feb 27.

View Dietary Reference Intakes (DRI) Values

Nutrition Information


Amount Per Serving
Nutrients per tablet
Energy kcal 2.1
Carbohydrate g 0.09
Fat g 0.009
   Trans g 0
Protein equivalent* g 0.41
Biotin μg 1.0
Vitamin B6 μg 50
Vitamin B12 μg 0.09
Folic Acid μg 6.5

1 tablet = 690 mg


L-Tyrosine, L-Leucine, Tricalcium Phosphate, L-Tryptophan, Potato Starch, L-Isoleucine, L-Valine, L-Lysine, L-Threonine, L-Arginine, L-Histidine, Colloidal Hydrated Silica, Rice Starch, L-Methionine, Shellac, Titanium Dioxide, Magnesium Stearate, Olive Oil, Macrogol 6000, Vitamin B6, Folic Acid, Biotin, Vitamin B12.

Directions for Use

Suggested Intake: 1 tablet per kg of body weight per day (1 tablet/kg/d).

Daily intake to be determined by your healthcare professional specialized in metabolic disorders. The dosage is dependant on the age, body weight, medical condition and individual Phe tolerance. NeoPhe is not suitable as a sole source of nutrition.

NeoPhe must always be taken with food. NeoPhe must be supplemented with a moderately restricted PKU diet containing other sources of protein, vitamins and minerals. An individualized diet plan must be followed at all times.


NeoPhe should not be used when planning a pregnancy or during a pregnancy.

Additional information

Weight 0.95 lbs
Dimensions 4 × 4 × 4 in


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