Description

Lower Blood Phe with NeoPhe.
Clinically proven combination of large neutral amino acids (LNAA) that block Phenylalanine at the gut level resulting in lower blood Phenylalanine.

Clinically Proven

  • Data from pilot studies conducted in Ukraine, Russia and the US revealed a decrease in blood Phe concentration of 52%-55% form baseline. When NeoPhe was discontinued, blood Phe concentrations increased to pre-trial levels. 1
  • Double blind studies performed in seven (7) different centers indicate that LNAA can compete with Phe on the transporter in the GI tract, resulting in a decrease in the blood phe-level in patients on NeoPhe, averaging 39% from baseline levels. 2

Indications

  • Adults, teenagers and children 8 years or older
  • BH4 non-responders
  • High blood Phe levels despite strong diet compliance
  • Non compliant, untreated or late-diagnosed PKU patients

Benefits

  • Monitor blood Phe levels for tolerance.
  • NeoPhe tablets and powder can be used interchangeably.
  • NeoPhe results in liberalization of the diet for most PKU patients.
  • Decrease in consumption of low protein foods.

References
1) R. Matalon, K.  Michals-Matalon, G. Bhatia, E. Grechanina, P. Novikov, D. J. McDonald, J. Grady, S.K. Tyring, F. Guttler, Large Neutral Amino Acids in the Treatment of Phenylketonuria (PKU), J Inherit Metab Dis. 2006 Dec;29(6):732-8. 
2)
 R. Matalon, K. Michals-Matalon, G. Bhatia, A.B. Burlina, A.P. Burlina, C. Braga, L. Fiori, M. Giovannini, E. Grechanina, P. Novikov, J. Grady, S.K. Tyring,  F.Guttler, Double blind placebo control trial of large neutral amino acids in treatment of PKU: Effect on blood phenylalanine. J Inherit Metab Dis. 2007, Feb 27.

View Dietary Reference Intakes (DRI) Values

Nutrition Information

Nutrients per 100 g powder
Energy kcal 315
Carbohydrate g 18.7
Fat g 0
   Trans g 0
Amino Acids g 73.5
Protein equivalent g 60.0
Vitamins    
Biotin μg 147
Vitamin B6 g 7.353
Vitamin B12 μg 13.2
Folic Acid μg 956

1 level scoop = 5.8 g powder = 4.2 g amino acids

Ingredients

L-Tyrosine, Fructose, L-Leucine, L-Tryptophan, L-Isoleucine, L-Valine, L-Lysine , Artificial Lemon Flavoring, L-Threonine, L-Arginine, L-Histidine, L-Methionine, Sucrose Palmitate, Magnesium, Silica, Sucralose, Riboflavin, Vitamin B6, Folic Acid, Biotin, Vitamin B12.

Directions for Use

Suggested Intake: 0.5 g amino acids per kg of body weight per day (0.5 g amino acids/kg/d).

Daily intake to be determined by your healthcare professional specialized in metabolic disorders. The dosage is dependant on the age, body weight, medical condition and individual Phe tolerance. NeoPhe is not suitable as a sole source of nutrition.

NeoPhe must always be taken with food. NeoPhe must be supplemented with a moderately restricted PKU diet containing other sources of protein, vitamins and minerals. An individualized diet plan must be followed at all times.

Additional information

Weight 0.95 lbs

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