Lower Blood Phe with NeoPhe.

Clinically proven combination of large neutral amino acids (LNAA) that block Phenylalanine at the gut level resulting in lower blood Phenylalanine.

Clinically Proven

• Data from pilot studies conducted in Ukraine, Russia and the US revealed a decrease in blood Phe concentration of 52%-55% form baseline. When NeoPhe was discontinued, blood Phe concentrations increased to pre-trial levels. ¹
• Double blind studies performed in seven (7) different centers indicate that LNAA can compete with Phe on the transporter in the GI tract, resulting in a decrease in the blood phe-level in patients on NeoPhe, averaging 39% from baseline levels. ²

Indications

• Adults, teenagers and children 8 years or older
• BH4 non-responders
• High blood Phe levels despite strong diet compliance
• Non compliant, untreated or late-diagnosed PKU patients

Warning

• NeoPhe should not be used when planning a pregnancy or during a pregnancy.

Benefits

• Monitor blood Phe levels for tolerance.
• NeoPhe tablets and powder can be used interchangeably.
• NeoPhe results in liberalization of the diet for most PKU patients.
• Decrease in consumption of low protein foods.

References

1) R. Matalon, K.  Michals-Matalon, G. Bhatia, E. Grechanina, P. Novikov, D. J. McDonald, J. Grady, S.K. Tyring, F. Guttler, Large Neutral Amino Acids in the Treatment of Phenylketonuria (PKU), J Inherit Metab Dis. 2006 Dec;29(6):732-8. 

2) R. Matalon, K. Michals-Matalon, G. Bhatia, A.B. Burlina, A.P. Burlina, C. Braga, L. Fiori, M. Giovannini, E. Grechanina, P. Novikov, J. Grady, S.K. Tyring,  F.Guttler, Double blind placebo control trial of large neutral amino acids in treatment of PKU: Effect on blood phenylalanine. J Inherit Metab Dis. 2007, Feb 27.

Ordering NeoPhe - (888) 876-5223

Contact Solace Nutrition
(888) 8-SOLACE (876-5223)
Fax: 401 633-6066
www.solacenutrition.com