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|Study on safety and bioavailability of ubiquinol (Kaneka QH™) after
single and 4-week multiple oral administration to healthy volunteers(PDF Format) The safety and bioavailability of ubiquinol (the reduced form of coenzyme Q10), a naturally occurring lipid-soluble nutrient, were evaluated for the Wrst time in single-blind, placebo-controlled studies with healthy subjects after administration of a single oral dose of 150 or 300mg and after oral administration of 90, 150, or 300mg for 4 weeks. No clinically relevant changes in results of standard laboratory tests, physical examination, vital signs, or ECG induced by ubiquinol were observed in any dosage groups.
|Ubiquinol-10 is an effective lipid-soluble antioxidant at
physiological concentrations(PDF Format) It is well known that ubiquinone-10 (coenzyme Q1o, ubiquinone 50) acts as an electron carrier of the respiratory chain in mitochondria. In this paper we show that ubiquinol-10, the reduced form of ubiquinone-10, also efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as ae-tocopherol, which is considered the best lipid-soluble antioxidant in humans. The number of radicals scavenged by each molecule of ubiquinol-10 is 1.1 under our experimental conditions. In contrast to a-tocopherol, ubiquinol-10 is not recycled by ascorbate. However, it is known that ubiquinol-10 can be recycled by electron transport carriers present in various biomembranes and possibly by some enzymes. We also show that ubiquinol-10 spares a-tocopherol when both antioxidants are present in the same liposomal membranes and that ubiquinol- 10, like a-tocopherol, does not interact with reduced glutathione. Our data together with previous work on the antioxidant function of ubiquinol reported in the literature strongly suggest that ubiquinol-10 is an important physiological lipidsoluble antioxidant.